The Systems Engineering Research Center (SERC) developed a set of research roadmaps to help plan and integrate core research areas across our network of university collaborators. The roadmaps cover three key transformational MBSE areas: improved security, velocity and agility, and artificial intelligence and automation. These are enabled by a fourth roadmap analyzing digital engineering and MBSE. Systems engineering will undergo a huge transformation over the next several years as digital engineering and related MBSE processes and tools mature. This presentation will discuss what we see as waves of transformation across these four areas, potential outcomes, and likely verticals of research and development.